Cousin regularity delivery out-of (a) SBP transform, (Gaussian fit Roentgen 2 for sodium delicate = 0.74 and sodium unwilling = 0 which is better eHarmony vs OkCupid.97) and you can (b) urinary Na + /K + , (Gaussian match R 2 getting sodium sensitive and painful = 0.99 and salt unwilling somebody = 0.99) on set of salt sensitive (letter = 71) and you can sodium resistant (n = 119) people with alter out of weight-loss input from Dietary Solutions to Prevent Blood pressure levels (DASH) high salt (HS) diet in order to Dash low salt (LS) diet plan.
Participant demographics
Certainly analysis people reviewed, 53% off SR and you can 62% of the SS people was basically ladies, 51% regarding SR and you will 63% from SS participants was basically African-American (Table step 1). The majority of members was indeed aged 31–55 ages, college-educated, and you can operating regular. There had been no tall variations in baseline characteristics to have investigation users round the ethnicity otherwise intercourse either in the latest SS or SR teams (Desk step one).
Baseline SBP, assessed during the screening visit prior to dietary intervention was significantly higher in SS (137.6 ± 8.7 mmHg) vs. SR participants (132.5 ± 9.6 mmHg; p < 0.05, Table 2). In contrast there was no significant difference in 24 h urinary Na + excretion, 24 h urinary K + excretion and the urinary Na + :K + ratio between SS and SR participants at screening (Table 2). Further, there was no significant effect of sex or ethnicity on these variables, as such subsequent analyses were not adjusted for age or ethnicity. In SS, but not SR participants, each additional g/day in urinary Na + excretion across the range of <2 g/day to 5 g/day resulted in a higher SBP value of approximately 1.0 ± 0.4 mmHg in SBP/g Na + excretion (Fig. 2a). The measures >5 g/day Na+ were not included due to increased sample variability. When assessed by linear regression across the entire range of observed Na + excretion we observed no correlation between urinary Na + excretion and SBP in either SS (R 2 = 0.02) or SR (R 2 = 0.02) participants (Fig. 2b). In both SS and SR participants urinary K + excretion of <1 g/day elevated SBP by 3.9 and 4.8 mmHg respectively vs. SBP values obtained for urinary excretion of 1–1.99gK + /day (Fig. 3a) and the Cohen's D score for the difference in the SBP among the participants with less than 1 g/day versus 1-1.9 g/day of urinary K + excretion showed a medium effect size in both SS (0.45) and the SR (0.49) group. However, when assessed across the entire range of observed K + excretion we observed no correlation between K + excretion and SBP in either SS (R 2 = 0.001) or SR (R 2 = 0.008) participants (Fig. 3b). Further, we observed no association between the urinary Na + :K + ratio and SBP and no impact of urinary K + excretion across any dietary Na + excretion range on SBP in either SS (R 2 = 0.004) or SR (R 2 = 0.002) participants (Fig. 4a, b).
Impact of Dash diet plan on organization of urinary sodium to potassium removal proportion with SBP
Within the sub group of SS participants randomly assigned to DASH-Sodium dietary intervention arm (N = 71) there was a significant (p < 0.05) reduction in SBP on the DASH-LS diet compared to the baseline screening SBP value (Table 3). In the sub group of SR participants randomly assigned to the DASH-Sodium intervention (N = 119) there were significant (p < 0.05) reductions in SBP on both the DASH-HS and DASH-LS diets compared to the baseline screening SBP value (Table 3). On the DASH-Sodium diet, following both the LS and HS interventions compared to screening there was a significant (p < 0.05) increase in urinary K + excretion and reduction in the urinary Na + :K + ratio (that was greater during the LS intervention), in both SS and SR participants (Table 3).